HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATION OF DERIVATIZED AMINO-ACIDS ENANTIOMERS USING MODIFIED BETA-CYCLODEXTRIN AS A MOBILE-PHASE ADDITIVE

被引：7
|
作者：
SPENCER, BJ [1 ]
PURDY, WC [1 ]
机构：
[1] MCGILL UNIV,DEPT CHEM,MONTREAL,PQ H3A 2K6,CANADA
来源：
ANALYTICAL LETTERS | 1995年 / 28卷 / 10期
关键词：
CYCLODEXTRINS; DERIVATIZED AMINO ACID ENANTIOMERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
D O I：
10.1080/00032719508000363
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Derivatized beta-cyclodextrin was used as a mobile phase additive for the liquid chromatographic resolution of amino acid derivative enantiomers with an achiral C-18 stationary phase. The separation and retention obtained with methyl-beta-cyclodextrin was compared with that of the unmodified beta-cyclodextrin at different mobile phase compositions. The effects of cyclodextrin concentration, pH, and methanol and buffer concentration on enantioselectivity and capacity factor were examined.
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页码：1865 / 1881
页数：17
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