AN ESTERASE WITH BETA-LACTAMASE ACTIVITY

被引：16

作者：

JONES, M ^{[1
]}

PAGE, MI ^{[1
]}

机构：

[1] HUDDERSFIELD POLYTECH,DEPT CHEM & PHYS SCI,HUDDERSFIELD HD1 3DH,W YORKSHIRE,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 05期

关键词：

D O I：

10.1039/c39910000316

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Porcine liver esterase selectively catalyses the hydrolysis of the beta-lactam of the methyl ester of benzylpenicillin with a k(cat)/K(m) of 675 dm3 mol-1 s-1 and without hydrolysing the methyl ester function.

引用

页码：316 / 317

页数：2

共 6 条

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[2] FIRESTONE RA, 1990, MOLECULAR MECHANISMS IN BIOORGANIC PROCESSES, P44
[3] A STEREOSELECTIVE ROUTE TO THE KEY INTERMEDIATE OF 1-BETA-METHYLCARBAPENEMS BY CHEMICOENZYMATIC APPROACH
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OHNO, M
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[4] THE MECHANISMS OF REACTIONS OF BETA-LACTAM ANTIBIOTICS
PAGE, MI
[J]. ADVANCES IN PHYSICAL ORGANIC CHEMISTRY, 1987, 23 : 165 - 270
[5] PAGE MI, 1990, COMPREHENSIVE MED CH, V1, P45
[6] ENZYMES IN ORGANIC-SYNTHESIS .47. ACTIVE-SITE MODEL FOR INTERPRETING AND PREDICTING THE SPECIFICITY OF PIG-LIVER ESTERASE
TOONE, EJ
WERTH, MJ
JONES, JB
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (12) : 4946 - 4952

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