SURFACTANT AND ISOPRENALINE EFFECT ON EUSTACHIAN-TUBE OPENING IN RATS WITH ACUTE OTITIS-MEDIA

被引：11

作者：

WHITE, P

HERMANSSON, A

SVINHUFVUD, M

机构：

[1] Department of Oto-Rhino-Laryngology, University Hospital, Lund

来源：

AMERICAN JOURNAL OF OTOLARYNGOLOGY | 1990年 / 11卷 / 06期

关键词：

eustachian tube function; rat; surfactant;

D O I：

10.1016/0196-0709(90)90117-E

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Purulent otitis media was induced in 12 middle ears of Sprague-Dawley rats by inoculation of pneumococci type 3. The pressure required to open the eustachian tube was recorded 4 days later and was found to be 3.05 ± 0.10 kPa (mean ± SEM), which was 1.08 ± 0.15 kPa lower than the mean value obtained in a control group of healthy rats (P ≤ .001). We also measured the effects of pulmonary surfactant instilled into the middle ear as well as isoprenaline injected intravenously. The presence of surfactant further reduced the pressure opening level by 0.72 ± 0.05 kPa; this reduction did not differ from that found in the control group (P > .8). Isoprenaline reduced the pressure opening level in the control group by 0.20 ± 0.03 kPa (P ≤ .001), and no reduction was found in the rats with otitis media. Although the part played by surface tension-lowering factors in eustachian tube function is still uncertain, such factors apparently also exert an effect in the inflamed tube. However, isoprenaline, which is considered to act by the secretion of surface tension-lowering substances, did not facilitate opening of the eustachian tube in rats with acute otitis media. © 1990.

引用

页码：389 / 392

页数：4

共 15 条

[1]

Jackson, Pharmacological mechanisms in the eustachian tube, Ann Otol Rhinol Laryngol, 81, pp. 268-271, (1972)

[2]

Sheffield, Jackson, Davis, Patency changes in dog's eustachian tube in response to alpha and beta adrenergic drugs, Ann Otol Rhinol Laryngol, 79, pp. 117-123, (1970)

[3]

Anggard, Malm, Oral administered decongestant drugs in disorders of the upper respiratory passages A survey of clinical results, Clinical Otolaryngology, 9, pp. 43-49, (1984)

[4]

Flisberg, Ingelstedt, Ortegren, The valve and “locking” mechanism of the eustachian tube, Acta Oto-laryngologica, 56, pp. 57-68, (1963)

[5]

Birken, Brookler, Surface tension lowering substance of the canine eustachian tube, Ann Otol, 81, pp. 268-271, (1972)

[6]

Hagan, Surface tension lowering substance in eustachian tube function, Laryngoscope, 87, pp. 1033-1045, (1977)

[7]

Maves, Patil, Lim, Surface-active substances of the guinea pig tubotympanum A chemical and physical analysis, Otolaryngol Head Neck Surg, 89, pp. 307-316, (1981)

[8]

Grace, Kwok, Hawke, Surfactant in middle ear effusion, Otolaryngol Head Neck Surg, 96, pp. 336-340, (1987)

[9]

Svane-Knudsen, Larsen, Brask, Secretory otitis media—A question of surface activity in the eustachian tube?, Acta Otolaryngol (Stockh), 105, pp. 114-119, (1988)

[10]

White, Effect of exogenous surfactant on the eustachian tube function in the rat, Am J Otolaryngol, 10, pp. 301-304, (1989)

← 1 2 →