Scientific Opinion on the safety and efficacy of alicyclic and aromatic lactones (chemical group 11) when used as flavourings for all animal species

被引：2

作者：

Aquilina, Gabriele ^{[1
]}

Bories, Georges ^{[1
]}

Chesson, Andrew ^{[1
]}

Cocconcelli, Pier Sandro ^{[1
]}

de Knecht, Joop ^{[1
]}

Dierick, Noel Albert ^{[1
]}

Gralak, Mikolaj Antoni ^{[1
]}

Gropp, Juergen ^{[1
]}

Halle, Ingrid ^{[1
]}

Hogstrand, Christer ^{[1
]}

Kroker, Reinhard ^{[1
]}

Leng, Lubomir ^{[1
]}

Puente, Secundino Lopez ^{[1
]}

Haldorsen, Anne-Katrine Lundebye ^{[1
]}

Mantovani, Alberto ^{[1
]}

Martelli, Giovanna ^{[1
]}

Mezes, Miklos ^{[1
]}

Renshaw, Derek ^{[1
]}

Saarela, Maria ^{[1
]}

Sejrsen, Kristen ^{[1
]}

Westendorf, Johannes ^{[1
]}

机构：

[1] European Food Safety Author EFSA, Parma, Italy

来源：

EFSA JOURNAL | 2012年 / 10卷 / 03期

关键词：

Sensory additives; flavourings; alicyclic lactones; aromatic lactones; chemical group 11; 3-propylidenephthalide; 3-butylidenephthalide; 3,4-dihydrocoumarin;

D O I：

10.2903/j.efsa.2012.2622

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The flavour compounds 3-propylidenephthalide, 3-butylidenephthalide and 3,4-dihydrocoumarin belong to chemical group 11, defined as 'alicyclic and aromatic lactones'. All three additives are currently authorised for use as flavours in food. The FEEDAP Panel was unable to perform an assessment of 3-butylidenephtalide because of the absence of data on the purity of the compound. The proposed use of 1 to 5 mg 3,4-dihydrocoumarin/kg complete feed was considered safe for all animal species with a margin of safety in the range from 5 to 18 fold. For 3-propylidenephthalide, the maximum safe level in feed would allow a use level of 1 mg/kg complete feed for all species with a margin of safety ranging from 1 to 2.5. Safe concentrations should be appropriately reduced if used in water for drinking. The narrow margin of safety would not allow the simultaneous administration of 3-propylidenephthalide in feed and water for drinking. No safety concern would arise for the consumer from the use of 3-propylidenephthalide and 3,4-dihydrocoumarin in animal nutrition. The material safety data sheets provided by the suppliers identified both compounds as irritant to skin, eye and the respiratory tract and harmful if swallowed. In addition 3,4-dihydrocoumarin has been shown to be a skin sensitizer. Based on QSAR modelling, 3,4-dihydrocoumarin and 3-propylidenephthalide at a dose of 5 and 1 mg/kg complete feed, respectively, are not expected to pose a risk to the environment. Since 3-propylidenephthalide and 3,4-dihydrocoumarin are used in food as flavourings, and their function in feed is essentially the same as that in food no further demonstration of efficacy was considered necessary. (C) European Food Safety Authority, 2012.

引用

页数：14

共 12 条

[1]

Born SL, 1997, DRUG METAB DISPOS, V25, P1318

[2]

EC (European Commission), 2006, AD SCI COMM CONS PRO

[3]

EFSA, 2009, EFSA J, V1169, P1

[4]

EFSA (European Food Safety Authority), 2008, EFSA J, V919, P1

[5]

Feuer G, 1966, Food Cosmet Toxicol, V4, P157, DOI 10.1016/S0015-6264(66)80459-5

[6] BIOCHEMICAL-CHARACTERIZATION OF COUMARIN 7-HYDROXYLASE ACTIVITY IN CHICK-EMBRYO LIVER-MICROSOMES [J].

GOEGER, DE ;

ANDERSON, KE .

BIOCHEMICAL PHARMACOLOGY, 1992, 43 (02) :363-369

[7]

JECFA, 2004, WHO FOOD ADDITIVES S, V52

[8]

JECFA, 2004, WHO TECHN REP SER, V922, P10

[9]

JECFA, 2006, ALL SPEC MON 1 65 M

[10] METABOLISM OF [3-C-14] COUMARIN [J].

KAIGHEN, M ;

WILLIAMS, RT .

JOURNAL OF MEDICINAL & PHARMACEUTICAL CHEMISTRY, 1961, 3 (01) :25-&

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