INHIBITION OF PROSTAGLANDIN BIOSYNTHESIS BY C-5,C-8,C-11-EICOSATRIENOIC ACID

被引：23
作者：
VANEVERT, WC
NUTEREN, DH
VANDORP, DA
机构：
[1] Unilever Research, Vlaardinge
来源：
PROSTAGLANDINS | 1978年 / 15卷 / 02期
关键词：
D O I：
10.1016/0090-6980(78)90165-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The enzyme prostaglandin H → E-isomerase (EC 5.3.99.3), which is present in sheep vesicular gland and needs glutathione as cofactor, is inhibited by c-5, c-8, c-11-eicosatrienoic acid, the fatty acid accumulating during essential fatty acid deficiency. The EFA-deficiency syndrome can partly be explained from a prostaglandin deficiency caused by lack of precursors. The present finding indicates that 5,8,11-eicosatrienoic acid could well be an additional factor in modifying the symptoms of EFA-deficiency. © 1978.
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页码：267 / 272
页数：6
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