PENTOXIFYLLINE DOES NOT PREVENT MICROVASCULAR INJURY IN NORMOTENSIVE, SEPTIC RATS

被引:13
作者
FLAMAND, FJ
SIBBALD, WJ
GIROTTI, MJ
MARTIN, CM
机构
[1] UNIV WESTERN ONTARIO,VICTORIA HOSP RES INST,PROGRAM CRIT CARE,AC BURTON VASC BIOL LAB,LONDON,ON N6A 4G5,CANADA
[2] UNIV WESTERN ONTARIO,VICTORIA HOSP RES INST,DEPT SURG,LONDON,ON,CANADA
关键词
SEPSIS; VASCULAR PERMEABILITY; ALBUMIN PENTOXIFYLLINE; EDEMA; TISSUE; ABDOMINAL SURGERY; CRITICAL ILLNESS;
D O I
10.1097/00003246-199501000-00020
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Objective: To determine if treatment with pentoxifylline would decrease the tissue injury that occurs in a normotensive model of sepsis. Design: Random assignment to control, cecal ligation-perforation, or cecal ligation-perforation plus pentoxifylline groups for a 24-hr study. Setting: Animal laboratory. Subjects: Male Sprague-Dawley rats. Interventions: Sepsis was induced by cecal ligation-perforation with aggressive fluid resuscitation (normal saline 10 mL/kg/hr), Pentoxifylline was administered as a 2-mg/kg bolus, followed by a continuous infusion of 6 mg/kg/hr. Measurements and Main Results: Compared with controls, rats in the cecal ligation-perforation group had an increased heart rate (432 +/- 12 vs, 399 +/- 10 beats/min) and respiratory rate (129 +/- 6 vs, 94 +/- 7 breaths/min). Blood pressure was slightly decreased (104 +/- 4 vs, 125 +/- 5 mm Hg), while cardiac index was not significantly different (50.1 +/- 5.7 vs, 40.7 +/- 3.9 mL/min/100 g). Blood pressure (103 +/- 4 mm Hg) was the only parameter that was significantly different in the cecal ligation-perforation plus pentoxifylline group compared with controls. When compared with controls, tissue wet/dry weight ratios were increased in the diaphragm of the cecal ligation-perforation group and in the liver, pancreas, small bowel, and large bowel of the cecal ligation-perforation, and the cecal ligation-perforation plus pentoxifylline groups. Tissue/plasma albumin ratios were increased in the diaphragm of the cecal ligation-perforation group and in the liver, pancreas, and large bowel of the cecal ligation-perforation and the cecal ligation-perforation plus pentoxifylline groups. There were no significant differences between the cecal ligation-perforation and the cecal ligation-perforation plus pentoxifylline groups. Conclusions: Normotensive sepsis is accompanied by increased vascular permeability in the diaphragm and intra-abdominal organs. Pentoxifylline appears to attenuate some of the systemic manifestations of sepsis. However, pentoxifylline did not prevent the development of protein-rich tissue edema.
引用
收藏
页码:119 / 124
页数:6
相关论文
共 33 条
[21]   DIFFERENTIAL IMPAIRMENT OF VASCULAR REACTIVITY OF SMALL PULMONARY AND SYSTEMIC ARTERIES IN HYPERDYNAMIC SEPSIS [J].
MARTIN, CM ;
YAGHI, A ;
SIBBALD, WJ ;
MCCORMACK, D ;
PATERSON, NAM .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 148 (01) :164-172
[22]  
MARTIN CM, 1992, PATHOPHYSIOLOGY SHOC, P1119
[23]   SENSITIVITY TO ENDOTOXIN IN RABBITS IS INCREASED AFTER HEMORRHAGIC-SHOCK [J].
MILESKI, WJ ;
WINN, RK ;
HARLAN, JM ;
RICE, CL .
JOURNAL OF APPLIED PHYSIOLOGY, 1992, 73 (03) :1146-1149
[24]  
MOVAT HZ, 1987, FED PROC, V42, P97
[25]  
Natanson C, 1989, J Cardiothorac Anesth, V3, P215, DOI 10.1016/S0888-6296(89)93026-3
[26]   A UNIFYING HYPOTHESIS OF MULTIPLE SYSTEMS ORGAN FAILURE - FAILURE OF HOST DEFENSE HOMEOSTASIS [J].
PINSKY, MR ;
MATUSCHAK, GM .
JOURNAL OF CRITICAL CARE, 1990, 5 (02) :108-114
[27]  
Robbins SL, 1981, BASIC PATHOLOGY, P28
[28]  
SHEPPARD BC, 1989, SURGERY, V106, P156
[29]   PULMONARY MICRO-VASCULAR CLEARANCE OF RADIOTRACERS IN HUMAN CARDIAC AND NONCARDIAC PULMONARY-EDEMA [J].
SIBBALD, WJ ;
DRIEDGER, AA ;
MOFFAT, JD ;
MYERS, ML ;
REID, BA ;
HOLLIDAY, RL .
JOURNAL OF APPLIED PHYSIOLOGY, 1981, 50 (06) :1337-1347
[30]   PRETREATMENT WITH PENTOXIFYLLINE IMPROVES THE HEMODYNAMIC AND HISTOLOGIC-CHANGES AND DECREASES NEUTROPHIL ADHESIVENESS IN A PIG FECAL PERITONITIS MODEL [J].
TIGHE, D ;
MOSS, R ;
HYND, J ;
BOGHOSSIAN, S ;
ALSAADY, N ;
HEATH, MF ;
BENNETT, ED .
CRITICAL CARE MEDICINE, 1990, 18 (02) :184-189