IMMUNOTOXINS IN THE THERAPY OF CANCER - FROM BENCH TO CLINIC

被引：38

作者：

GHETIE, V

VITETTA, E

机构：

[1] UNIV TEXAS, SW MED CTR, DEPT MICROBIOL, DALLAS, TX 75235 USA

[2] UNIV TEXAS, SW MED CTR, CTR CANC IMMUNOBIOL, DALLAS, TX 75235 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 1994年 / 63卷 / 03期

关键词：

IMMUNOTOXIN; MONOCLONAL ANTIBODY; CANCER; THERAPY;

D O I：

10.1016/0163-7258(94)90025-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review presents only those contributions that have progressed from the bench to the clinic using murine monoclonal antibodies coupled chemically to toxins, their subunits or ribosome-inactivating proteins. The rationale and progress in the development, characterization, preclinical testing and clinical trials are discussed.

引用

页码：209 / 234

页数：26

共 128 条

[11] BYERS VS, 1987, CANCER RES, V47, P5042
[12] BYERS VS, 1987, CANCER RES, V47, P5277
[13] BYERS VS, 1989, CANCER RES, V49, P6153
[14] TARGETED KILL - FROM UMBRELLAS TO MONOCLONAL-ANTIBODIES
BYERS, VS
BALDWIN, RW
[J]. JOURNAL OF CLINICAL IMMUNOLOGY, 1992, 12 (06) : 391 - 405
[15] CAMPANA D, 1985, J IMMUNOL, V134, P1524
[16] CURTI BD, 1993, CANCER RES, V53, P2204
[17] DEBINSKI W, 1992, CANCER RES, V52, P5379
[18] AN IMMUNOTOXIN WITH INCREASED ACTIVITY AND HOMOGENEITY PRODUCED BY REDUCING THE NUMBER OF LYSINE RESIDUES IN RECOMBINANT PSEUDOMONAS EXOTOXIN
DEBINSKI, W
PASTAN, I
[J]. BIOCONJUGATE CHEMISTRY, 1994, 5 (01) : 40 - 46
[19] DEROCQ JM, 1988, J IMMUNOL, V141, P2837
[20] DORIA MI, 1988, CANCER, V62, P1939, DOI 10.1002/1097-0142(19881101)62:9<1939::AID-CNCR2820620912>3.0.CO

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