IMMUNOTOXINS IN THE THERAPY OF CANCER - FROM BENCH TO CLINIC

被引：38
作者：
GHETIE, V
VITETTA, E
机构：
[1] UNIV TEXAS, SW MED CTR, DEPT MICROBIOL, DALLAS, TX 75235 USA
[2] UNIV TEXAS, SW MED CTR, CTR CANC IMMUNOBIOL, DALLAS, TX 75235 USA
来源：
PHARMACOLOGY & THERAPEUTICS | 1994年 / 63卷 / 03期
关键词：
IMMUNOTOXIN; MONOCLONAL ANTIBODY; CANCER; THERAPY;
D O I：
10.1016/0163-7258(94)90025-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This review presents only those contributions that have progressed from the bench to the clinic using murine monoclonal antibodies coupled chemically to toxins, their subunits or ribosome-inactivating proteins. The rationale and progress in the development, characterization, preclinical testing and clinical trials are discussed.
引用
收藏
页码：209 / 234
页数：26
相关论文
共 128 条
  • [1] AMLOT PL, 1993, BLOOD, V82, P2624
  • [2] EXPRESSION OF HUMAN B CELL-ASSOCIATED ANTIGENS ON LEUKEMIAS AND LYMPHOMAS - A MODEL OF HUMAN B-CELL DIFFERENTIATION
    ANDERSON, KC
    BATES, MP
    SLAUGHENHOUPT, BL
    PINKUS, GS
    SCHLOSSMAN, SF
    NADLER, LM
    [J]. BLOOD, 1984, 63 (06) : 1424 - 1433
  • [3] BARBIERI L, 1989, EUR J HAEMATOL, V42, P238
  • [4] INSERTION OF CONSTANT REGION DOMAINS OF HUMAN IGG(1) INTO CD4-PE40 INCREASES ITS PLASMA HALF-LIFE
    BATRA, JK
    KASTURI, S
    GALLO, MG
    VOORMAN, RL
    MAIO, SM
    CHAUDHARY, VK
    PASTAN, I
    [J]. MOLECULAR IMMUNOLOGY, 1993, 30 (04) : 379 - 386
  • [5] BJORN MJ, 1985, CANCER RES, V45, P1214
  • [6] BOOKMAN MA, 1990, INT S IMMUNOTOXIN, V15
  • [7] BOOKMAN MA, 1990, ANTIBODY IMMUNOCONJ, V3, P70
  • [8] B3(FV)-PE38KDEL, A SINGLE-CHAIN IMMUNOTOXIN THAT CAUSES COMPLETE REGRESSION OF A HUMAN CARCINOMA IN MICE
    BRINKMANN, U
    PAI, LH
    FITZGERALD, DJ
    WILLINGHAM, M
    PASTAN, I
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (19) : 8616 - 8620
  • [9] BUNN PA, 1985, BLOOD, V65, P764
  • [10] Byers V S, 1991, Semin Cell Biol, V2, P59
12345678910