A PREPARATION OF HIGH SPECIFIC ACTIVITY [11,12-H-3]-9-CIS-RETINOIC ACID

被引：3

作者：

COE, JW ^{[1
]}

HAWES, CR ^{[1
]}

TOWERS, P ^{[1
]}

机构：

[1] AMERSHAM INT PLC,CARDIFF LABS,FOREST FARM,CARDIFF,S GLAM CF4 7YT,WALES

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1995年 / 36卷 / 06期

关键词：

9-CIS-RETINOIC ACID; DEUTERUIM; TRITIUM; HIGH SPECIFIC ACTIVITY;

D O I：

10.1002/jlcr.2580360610

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A selective total synthesis of [11,12-H-3]-9-cis-retinoic acid 1 at a specific activity of 46 Ci/mmole is described. The alkyne 4, efficiently prepared in two steps from readily available starting materials, was partially reduced to 9,11-di-cis-retinoic acid 3 with both deuterium and tritium gas. Selective isomerization of 3 to 1 is discussed, as well as non-selective direct conversions of 4 to 1.

引用

页码：587 / 594

页数：8

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