ENHANCED INHIBITION OF THYMIDYLATE SYNTHASE BY 5-FLUOROURACIL AND [6S]LEUCOVORIN COMBINATION THERAPY FOR BREAST-CANCER

被引：0

作者：

TOMINAGA, T ^{[1
]}

TOI, M ^{[1
]}

SHIRASAKA, T ^{[1
]}

机构：

[1] TAISHO PHARMACEUT CO LTD,CTR ORIGINAL COMPOUND R&D OPERAT,PATHOGEN BIOCHEM MED LAB,HANNO,SAITAMA 357,JAPAN

来源：

ANTICANCER RESEARCH | 1993年 / 13卷 / 6B期

关键词：

6S]LEUCOVORIN; 5-FLUOROURACIL; BREAST CANCER; COMBINATION TREATMENT; THYMIDYLATE SYNTHASE; PREOPERATIVE CHEMOTHERAPY; TOTAL TS ACTIVITY; FREE TS ACTIVITY; RATE OF TS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The influence of the addition of [6S] leucovorin (LV) to 5-fluorouracil (5-FU) preoperative chemotherapy was examined in patients with surgically resectable breast cancer who had had no prior treatment. The patients underwent one of the following three treatments at their will: (1) 5-FU 500 mg/m(2) administered by an IV bolus; (2) [6S]LV 250 mg/m(2) infused intravenously over two hours, with 5-FU 500 mg/m(2) as an IV bolus at the midpoint of [6S]LV infusion, (3) no drug treatment. Tumors were resected 24 hours after the dose of 5-FU with or without [6S]LV. These studies confirmed an increased stabilization of 5-fluorodeoxyuridine monophosphate (FdUMP)-thymidylate synthase(TS)-folate ternary complex with the addition of [6S]LV. An increase of total TS activity was also found.

引用

页码：2425 / 2427

页数：3

共 10 条

[1]

BERGER H, 1986, P AACR, V27, P298

[2] CONCURRENT ALLOPURINOL AND 5-FLUOROURACIL - 5-FLUORO-2'-DEOXYURIDYLATE FORMATION AND THYMIDYLATE SYNTHASE INHIBITION IN RAT COLON-CARCINOMA AND IN REGENERATING RAT-LIVER [J].