IMPAIRED 1,25-DIHYDROXYVITAMIN-D PRODUCTION IN PREGNANCY-INDUCED HYPERTENSION

被引：23

作者：

FROLICH, A

RUDNICKI, M

STORM, T

RASMUSSEN, N

HEGEDUS, L

机构：

[1] MINERAL METAB RES GRP,COPENHAGEN,DENMARK

[2] HVIDOVRE UNIV HOSP,DEPT OBSTET & GYNECOL,DK-2650 HVIDOVRE,DENMARK

[3] SUNDBY HOSP,DEPT MED,SUNDBY,DENMARK

[4] GENTOFTE HOSP,DEPT GYNECOL & OBSTET,DK-2900 COPENHAGEN,DENMARK

[5] HERLEV HOSP,DEPT INTERNAL MED & ENDOCRINOL,DK-2730 HERLEV,DENMARK

[6] UNIV COPENHAGEN,DK-1168 COPENHAGEN,DENMARK

来源：

EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 1992年 / 47卷 / 01期

关键词：

DIHYDROXYCHOLECALCIFEROL; HYDROXYCHOLECALCIFEROL; HYPERTENSION; IONIZED CALCIUM; PARATHYROID HORMONE; PREGNANCY;

D O I：

10.1016/0028-2243(92)90210-P

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The aim of the study was to evaluate the calcium metabolism in pregnancy-induced hypertension. Fifty-three women with pregnancy-induced hypertension were studied and the control groups comprised 20 women with uncomplicated pregnancies in the third trimester and 51 non-pregnant women, respectively. The mean serum concentrations of 1,25-dihydroxyvitamin D in women with pregnancy-induced hypertension was low (38.6 +/- 21.4 pg/ml) compared to women with uncomplicated pregnancies (91.0 +/-18.2 pg/ml), but comparable to levels in non-pregnant women (32.2 +/- 11.9 pg/ml). Mean serum levels of PTH and ionized calcium were comparable in women with pregnancy-induced hypertension and women with uncomplicated pregnancies. In conclusion, the calcium metabolism in pregnancy-induced hypertension was changed compared to uncomplicated pregnancies with respect to the serum concentration of 1,25-dihydroxyvitamin D.

引用

页码：25 / 29

页数：5

共 21 条

[1]

ANDERSEN T, 1984, MINER ELECTROL METAB, V10, P316

[2] THE RELATIONSHIP BETWEEN CALCIUM INTAKE AND PREGNANCY-INDUCED HYPERTENSION - UP-TO-DATE EVIDENCE [J].

BELIZAN, JM ;

VILLAR, J ;

REPKE, J .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1988, 158 (04) :898-902

[3]

BRUNS ME, 1983, ANN CLIN LAB SCI, V13, P521

[4] SERUM PARATHYROID-HORMONE (PTH) IN PREGNANT-WOMEN DETERMINED BY AN IMMUNORADIOMETRIC ASSAY FOR INTACT PTH [J].

DAVIS, OK ;

HAWKINS, DS ;

RUBIN, LP ;

POSILLICO, JT ;

BROWN, EM ;

SCHIFF, I .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 67 (04) :850-852

[5]

DELUCA HF, 1983, BONE MINERAL RES ANN, V1, P7

[6] SERUM CONCENTRATIONS OF INTACT PARATHYROID-HORMONE DURING LATE HUMAN-PREGNANCY - A LONGITUDINAL-STUDY [J].

FROLICH, A ;

RUDNICKI, M ;

FISCHERRASMUSSEN, W ;

OLOFSSON, K .

EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 1991, 42 (02) :85-87

[7] EVIDENCE FOR EXTRA-RENAL 1 ALPHA-HYDROXYLATION OF 25-HYDROXYVITAMIN-D3 IN PREGNANCY [J].

GRAY, TK ;

LESTER, GE ;

LORENC, RS .

SCIENCE, 1979, 204 (4399) :1311-1313

[8] HYPOCALCIURIA IN HYPERTENSIVE DISORDER IN PREGNANCY AND HOW TO MEASURE IT [J].

HUIKESHOVEN, FJM ;

ZUIJDERHOUDT, FMJ .

EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 1990, 36 (1-2) :81-85

[9] ELEVATED 1,25-DIHYDROXYVITAMIN-D PLASMA-LEVELS IN NORMAL HUMAN PREGNANCY AND LACTATION [J].

KUMAR, R ;

COHEN, WR ;

SILVA, P ;

EPSTEIN, FH .

JOURNAL OF CLINICAL INVESTIGATION, 1979, 63 (02) :342-344

[10] PLASMA 1,25-DIHYDROXYVITAMIN-D LEVELS IN PREGNANCY AND LACTATION [J].

LUND, B ;

SELNES, A .

ACTA ENDOCRINOLOGICA, 1979, 92 (02) :330-335

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