CYTOKINE RECEPTORS AND SIGNAL TRANSDUCTION

被引:235
作者
MIYAJIMA, A
KITAMURA, T
HARADA, N
YOKOTA, T
ARAI, K
机构
[1] UNIV TOKYO, INST MED SCI, DEPT MOLEC & DEV BIOL, MINATO KU, TOKYO 108, JAPAN
[2] DNAX RES INST MOLEC & CELLULAR BIOL INC, DEPT IMMUNOL, PALO ALTO, CA 94304 USA
关键词
D O I
10.1146/annurev.iy.10.040192.001455
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Cytokines play a vital role in coordinating immune and inflammatory responses. Unlike growth factor receptors with a tyrosine kinase, cytokine receptors have no intrinsic tyrosine kinase activity. Based on their structure, cytokine receptors are classified into several groups. High affinity receptors for IL-2, IL-3, IL-5, IL-6, and GM-CSF are composed of at least two distinct subunits, alpha and beta. The alpha-subunits are primary cytokine binding proteins, and the beta-subunits are required for formation of high affinity binding sites as well as for signal transduction. The GM-CSF, IL-3, and IL-5 receptors appear to share the same beta-subunit in human, and therefore cross-talk among these cytokines may occur at the receptor level. High affinity receptors presumably are linked to various signal transduction pathways that lead to different cytokine functions. Differential expression of the cytokine receptors as well as reorganization of intracellular signalling pathways are critical for development of hemopoietic cells.
引用
收藏
页码:295 / 331
页数:37
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