REDOX CHEMISTRY OF COMPLEXES OF NICKEL(II) WITH SOME BIOLOGICALLY IMPORTANT PEPTIDES IN THE PRESENCE OF REDUCED OXYGEN SPECIES - AN ESR STUDY

被引：31

作者：

COTELLE, N ^{[1
]}

TREMOLIERES, E ^{[1
]}

BERNIER, JL ^{[1
]}

CATTEAU, JP ^{[1
]}

HENICHART, JP ^{[1
]}

机构：

[1] INSERM, U16, PL VERDUN, F-59045 LILLE, FRANCE

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1992年 / 46卷 / 01期

关键词：

D O I：

10.1016/0162-0134(92)80058-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The reactions between some Ni(II) oligopeptides (Gly-His-Lys, (Gly)4, Asp-Ala-His-Lys, Gly-Gly-His, beta-Ala-His, and serum albumin) and reduced oxygen species have been characterized by spin-trapping experiments using DMPO and Me2SO. Most of the peptides possessed superoxide dismutase- and catalase-like activities leading to the formation of either oxene [NiO]2+ or, in the case of beta-Ala-His, hydroxyl radicals. Both these species may affect DNA integrity through distinct mechanisms.

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页码：7 / 15

页数：9

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