ENDOTHELIN-1 ACUTELY STIMULATES THE SECRETORY ACTIVITY OF RAT ZONA GLOMERULOSA CELLS

被引：33
|
作者：
MAZZOCCHI, G
MALENDOWICZ, LK
NUSSDORFER, GG
机构：
[1] UNIV PADUA,DEPT ANAT,VIA GABELLI 65,I-35121 PADUA,ITALY
[2] POZNAN MED ACAD,DEPT HISTOL,PL-60781 POZNAN,POLAND
来源：
PEPTIDES | 1990年 / 11卷 / 04期
关键词：
Aldosterone; Dispersed cells; Endothelin-1; Rat; Zona glomerulosa;
D O I：
10.1016/0196-9781(90)90192-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A bolus IV injection of endothelin-1 (ET-1) (0.5 μg·kg-1) decreased PRA, without affecting plasma aldosterone (A) concentration. ET-1 exerted a dose-dependent stimulation of basal secretion of A and corticosterone (B) by dispersed zona glomerulosa (ZG) cells, while it did not affect B production by inner adrenocortical cells. ET-1 notably enhanced the secretory response of dispersed ZG cells to a maximal effective concentration of ACTH, but not of either angiotensin II (ANG-II) or potassium. The conclusion is drawn that ET-1 acutely stimulates ZG in rats, by a mechanism probably similar to that underlying the adrenoglomerulotropic actions of ANG-II and potassium. © 1990.
引用
收藏
页码：763 / 765
页数：3
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