NEURONAL MONOAMINE REUPTAKE INHIBITORS ENHANCE IN-VITRO SUSCEPTIBILITY TO CHLOROQUINE IN RESISTANT PLASMODIUM-FALCIPARUM

被引:29
作者
COUTAUX, AF
MOONEY, JJ
WIRTH, DF
机构
[1] HARVARD UNIV,SCH PUBL HLTH,DEPT TROP PUBL HLTH,BOSTON,MA 02115
[2] HARVARD UNIV,SCH MED,MASSACHUSETTS MENTAL HLTH CTR,BOSTON,MA 02115
关键词
D O I
10.1128/AAC.38.6.1419
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Chloroquine resistance in Plasmodium falciparum was reversed in vitro by the neuronal monoamine reuptake inhibitors and antidepressants desipramine, sertraline, fluoxetine, and norfluoxetine but not by carbamazepine, an antiseizure and mood-stabilizing tricyclic drug resembling desipramine which only weakly inhibits neuronal monoamine reuptake. These findings have important clinical implications for drug combination therapy.
引用
收藏
页码:1419 / 1421
页数:3
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