TRANSFORMING GROWTH-FACTOR-BETA IN RAT-KIDNEY DURING COMPENSATORY RENAL GROWTH

被引：0
|
作者：
KANDA, S
IGAWA, T
TAIDE, M
EGUCHI, J
NAKAMURA, M
NOMATA, K
YAMADA, J
KANETAKE, H
SAITO, Y
机构：
来源：
GROWTH REGULATION | 1993年 / 3卷 / 02期
关键词：
TRANSFORMING GROWTH FACTOR-BETA (TGF-BETA); RENAL HYPERPLASIA; NEPHRECTOMY; COMPENSATORY RENAL GROWTH; RENAL TUBULAR CELLS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Transforming growth factor-beta (TGF-beta) inhibits the DNA synthesis and stimulates the alkaline phosphatase activity of cultured renal cortical tubular cells. When unilateral nephrectomy was performed, TGF-beta activity content gradually decreased in the remaining kidney. An immunohistochemical study of the remaining kidney after uninephrectomy, however, showed that the expression of TGF-beta increased by the third day after uninephrectomy in the proximal tubular cells and an autoradiographic study revealed that TGF-beta expressing tubular cells were different from proliferating cells during compensatory renal growth. These results indicate that the total renal TGF-beta content decreases after uninephrectomy, while the expression of TGF-beta in the proximal tubular cells may increase and act as a brake for compensatory renal hyperplasia.
引用
收藏
页码：146 / 150
页数：5
相关论文
共 50 条
  • [31] TRANSFORMING GROWTH-FACTOR-BETA IN TEGUMENTARY LEISHMANIASIS
    BARRALNETTO, M
    BARRAL, A
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1994, 27 (01) : 1 - 9
  • [32] TRANSFORMING GROWTH-FACTOR-BETA IN GLOMERULAR INJURY
    BORDER, WA
    NOBLE, NA
    EXPERIMENTAL NEPHROLOGY, 1994, 2 (01): : 13 - 17
  • [33] TISSUE LOCALIZATION OF TRANSFORMING GROWTH-FACTOR-BETA IN THE FETAL AND POSTNATAL RAT
    ELSTOW, SF
    HILL, DJ
    STRAIN, AJ
    SWENNE, I
    CRACE, CJ
    MILNER, RDG
    JOURNAL OF ENDOCRINOLOGY, 1986, 108 : 218 - 218
  • [34] PRODUCTION OF TRANSFORMING GROWTH-FACTOR-BETA BY CULTURED RAT MESANGIAL CELLS
    YAO, J
    LI, LS
    SHIMIZU, F
    OITE, T
    CHINESE MEDICAL JOURNAL, 1995, 108 (11) : 820 - 824
  • [35] TRANSFORMING GROWTH-FACTOR-BETA EXPRESSION IN THE HEART AND AORTA OF THE HYPERTENSIVE RAT
    NICKERSON, CJ
    PAVLOVARESOKOVA, A
    CHOBANIAN, AV
    BRECHER, P
    FASEB JOURNAL, 1994, 8 (07): : A1460 - A1460
  • [36] TRANSFORMING GROWTH-FACTOR-BETA AND THE INITIATION OF CHONDROGENESIS AND OSTEOGENESIS IN THE RAT FEMUR
    JOYCE, ME
    ROBERTS, AB
    SPORN, MB
    BOLANDER, ME
    CLINICAL RESEARCH, 1990, 38 (02): : A407 - A407
  • [37] BONE INDUCTION AND TRANSFORMING GROWTH-FACTOR-BETA
    ROSEN, DM
    NATHAN, R
    ARMSTRONG, R
    BENTZ, H
    THOMPSON, A
    DELEON, E
    BUCKMAN, E
    FIEDLER, L
    SEYEDIN, S
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 593 : 98 - 106
  • [38] TRANSFORMING GROWTH-FACTOR-BETA AND HEPATIC MITOCHONDRIA
    WILLIAMS, AO
    KNAPTON, AD
    LETTERIO, JJ
    GEISER, AD
    ROBERTS, AB
    MOLECULAR BIOLOGY OF THE CELL, 1995, 6 : 1925 - 1925
  • [39] TRANSFORMING GROWTH-FACTOR-BETA INHIBIN FAMILY
    ROBERTSON, DM
    BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM, 1991, 5 (04): : 615 - 634
  • [40] MEDIATION OF CARDIOPROTECTION BY TRANSFORMING GROWTH-FACTOR-BETA
    LEFER, AM
    TSAO, P
    AOKI, N
    PALLADINO, MA
    SCIENCE, 1990, 249 (4964) : 61 - 64
12345