TRANSFORMING GROWTH-FACTOR-BETA IN RAT-KIDNEY DURING COMPENSATORY RENAL GROWTH

被引：0
|
作者：
KANDA, S
IGAWA, T
TAIDE, M
EGUCHI, J
NAKAMURA, M
NOMATA, K
YAMADA, J
KANETAKE, H
SAITO, Y
机构：
来源：
GROWTH REGULATION | 1993年 / 3卷 / 02期
关键词：
TRANSFORMING GROWTH FACTOR-BETA (TGF-BETA); RENAL HYPERPLASIA; NEPHRECTOMY; COMPENSATORY RENAL GROWTH; RENAL TUBULAR CELLS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Transforming growth factor-beta (TGF-beta) inhibits the DNA synthesis and stimulates the alkaline phosphatase activity of cultured renal cortical tubular cells. When unilateral nephrectomy was performed, TGF-beta activity content gradually decreased in the remaining kidney. An immunohistochemical study of the remaining kidney after uninephrectomy, however, showed that the expression of TGF-beta increased by the third day after uninephrectomy in the proximal tubular cells and an autoradiographic study revealed that TGF-beta expressing tubular cells were different from proliferating cells during compensatory renal growth. These results indicate that the total renal TGF-beta content decreases after uninephrectomy, while the expression of TGF-beta in the proximal tubular cells may increase and act as a brake for compensatory renal hyperplasia.
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页码：146 / 150
页数：5
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