TRANSFORMING GROWTH-FACTOR-BETA IN RAT-KIDNEY DURING COMPENSATORY RENAL GROWTH

被引：0
|
作者：
KANDA, S
IGAWA, T
TAIDE, M
EGUCHI, J
NAKAMURA, M
NOMATA, K
YAMADA, J
KANETAKE, H
SAITO, Y
机构：
来源：
GROWTH REGULATION | 1993年 / 3卷 / 02期
关键词：
TRANSFORMING GROWTH FACTOR-BETA (TGF-BETA); RENAL HYPERPLASIA; NEPHRECTOMY; COMPENSATORY RENAL GROWTH; RENAL TUBULAR CELLS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Transforming growth factor-beta (TGF-beta) inhibits the DNA synthesis and stimulates the alkaline phosphatase activity of cultured renal cortical tubular cells. When unilateral nephrectomy was performed, TGF-beta activity content gradually decreased in the remaining kidney. An immunohistochemical study of the remaining kidney after uninephrectomy, however, showed that the expression of TGF-beta increased by the third day after uninephrectomy in the proximal tubular cells and an autoradiographic study revealed that TGF-beta expressing tubular cells were different from proliferating cells during compensatory renal growth. These results indicate that the total renal TGF-beta content decreases after uninephrectomy, while the expression of TGF-beta in the proximal tubular cells may increase and act as a brake for compensatory renal hyperplasia.
引用
收藏
页码：146 / 150
页数：5
相关论文
共 50 条
  • [1] LOCALIZATION OF TRANSFORMING GROWTH-FACTOR-BETA AND LATENT TRANSFORMING GROWTH-FACTOR-BETA BINDING-PROTEIN IN RAT-KIDNEY
    ANDO, T
    OKUDA, S
    TAMAKI, K
    YOSHITOMI, K
    FUJISHIMA, M
    KIDNEY INTERNATIONAL, 1995, 47 (03) : 733 - 739
  • [2] TRANSFORMING GROWTH-FACTOR-BETA AND THE KIDNEY
    KETTELER, M
    NOBLE, NA
    BORDER, WA
    JOURNAL OF NEPHROLOGY, 1995, 8 (03) : 143 - 147
  • [3] THE TRANSFORMING GROWTH-FACTOR-BETA SYSTEM AND THE KIDNEY
    SHARMA, K
    ZIYADEH, FN
    SEMINARS IN NEPHROLOGY, 1993, 13 (01) : 116 - 128
  • [4] TRANSFORMING GROWTH-FACTOR-BETA ENHANCES THE EXTENT OF INTERCELLULAR COMMUNICATION BETWEEN NORMAL RAT-KIDNEY CELLS
    VANZOELEN, EJJ
    TERTOOLEN, LGJ
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1991, 266 (18) : 12075 - 12081
  • [5] ORTHOVANADATE BOTH MIMICS AND ANTAGONIZES THE TRANSFORMING GROWTH-FACTOR-BETA ACTION ON NORMAL RAT-KIDNEY CELLS
    RIJKSEN, G
    VOLLER, MCW
    VANZOELEN, EJJ
    JOURNAL OF CELLULAR PHYSIOLOGY, 1993, 154 (02) : 393 - 401
  • [6] EFFECTS OF TRANSFORMING GROWTH-FACTOR-BETA ON COLLAGEN-SYNTHESIS BY NORMAL RAT-KIDNEY EPITHELIAL-CELLS
    CREELY, JJ
    DIMARI, SJ
    HOWE, AM
    HARALSON, MA
    AMERICAN JOURNAL OF PATHOLOGY, 1992, 140 (01): : 45 - 55
  • [7] GLOMERULOSCLEROSIS INDUCED BY IN-VIVO TRANSFECTION OF TRANSFORMING GROWTH-FACTOR-BETA OR PLATELET-DERIVED GROWTH-FACTOR GENE INTO THE RAT-KIDNEY
    ISAKA, Y
    FUJIWARA, Y
    UEDA, N
    KANEDA, Y
    KAMADA, T
    IMAI, E
    JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (06): : 2597 - 2601
  • [8] TRANSFORMING GROWTH-FACTOR-BETA
    MASSAGUE, J
    CHEIFETZ, S
    LAIHO, M
    RALPH, DA
    WEIS, FMB
    ZENTELLA, A
    CANCER SURVEYS, 1992, 12 : 81 - 103
  • [9] IMMUNOLOCALIZATION OF TRANSFORMING GROWTH-FACTOR-BETA IN RAT MOLARS
    WISE, GE
    FAN, W
    JOURNAL OF ORAL PATHOLOGY & MEDICINE, 1991, 20 (02) : 74 - 80
  • [10] PHENOTYPIC TRANSFORMATION OF NORMAL RAT-KIDNEY CELLS BY TRANSFORMING GROWTH-FACTOR-BETA IS NOT PARALLELED BY ENHANCED PRODUCTION OF A PLATELET-DERIVED GROWTH-FACTOR
    VANZOELEN, EJJ
    VANROTTERDAM, W
    WARDVANOOSTWAARD, TMJ
    FEIJEN, A
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 209 (01): : 89 - 94
12345