INDUCTION OF INTERFERON AND OTHER CYTOKINES BY IMIQUIMOD AND ITS HYDROXYLATED METABOLITE R-842 IN HUMAN BLOOD-CELLS IN-VITRO

被引：87

作者：

WEEKS, CE ^{[1
]}

GIBSON, SJ ^{[1
]}

机构：

[1] THREE M CO,PHARMACEUT,DEPT PHARMACOL,ST PAUL,MN 55144

来源：

JOURNAL OF INTERFERON RESEARCH | 1994年 / 14卷 / 02期

关键词：

D O I：

10.1089/jir.1994.14.81

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The low-molecular-weight immunomodulator drug candidate, imiquimod (R-837), and its hydroxylated metabolite R-842, induce interferon-alpha (IFN-alpha) in human blood cells in vitro when tested in concentrations of 0.5 mu g/ml or more. The amounts of IFN-alpha found increased with time from 2-6 h of incubation up to 24-48 h, and were dependent on cell number and drug concentration. These two chemicals yielded more IFN-alpha in human peripheral blood mononuclear cell (PBMC) cultures than other known inducers tested in parallel. They also induced detectable amounts of interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor-alpha in human PBMC cultures in vitro.

引用

页码：81 / 85

页数：5

共 22 条

[1] EFFECTS OF THE IMMUNOMODULATING AGENT R837 ON ACUTE AND LATENT HERPES-SIMPLEX VIRUS TYPE-2 INFECTIONS [J].