MICROBIAL OXIDATION OF THE ANTIMALARIAL DRUG ARTEETHER

被引：21

作者：

HU, YL ^{[1
]}

ZIFFER, H ^{[1
]}

LI, GY ^{[1
]}

YEH, HJC ^{[1
]}

机构：

[1] NIDDK,ANALYT CHEM LAB,BETHESDA,MD 20892

来源：

BIOORGANIC CHEMISTRY | 1992年 / 20卷 / 02期

关键词：

D O I：

10.1016/0045-2068(92)90035-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three oxidation products from the action of the enzymes in Beauveria sulfurescens on the antimalarial drug arteether were isolated and their structures established by mass spectrometry, and both 1D and 2D NMR. Two of the compounds, 14-hydroxyarteether and 9β-hydroxyarteether retained the peroxide bridge required for biological activity. The metabolites were employed as intermediates for the preparation of other products. © 1992.

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页码：148 / 154

页数：7

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