IS FATAL PANCREATITIS A CONSEQUENCE OF EXCESSIVE LEUKOCYTE STIMULATION - THE ROLE OF TUMOR-NECROSIS-FACTOR-ALPHA

被引：43

作者：

BANKS, RE

EVANS, SW

ALEXANDER, D

MCMAHON, MJ

WHICHER, JT

机构：

[1] UNIV LEEDS, OLD MED SCH, DEPT CHEM PATHOL, LEEDS LS2 9JT, W YORKSHIRE, ENGLAND

[2] UNIV LEEDS, GEN INFIRM, DEPT SURG, LEEDS LS1 3EX, W YORKSHIRE, ENGLAND

来源：

CYTOKINE | 1991年 / 3卷 / 01期

关键词：

ALPHA1 PROTEINASE INHIBITOR; ELASTASE; LEUKOCYTES; PANCREATITIS; TNF;

D O I：

10.1016/1043-4666(91)90004-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study examines the possible role of excessive leukocyte stimulation in the pathogenesis of acute pancreatitis. Levels of tumor necrosis factor α (TNF-α) and elastase-α1 proteinase inhibitor (E-α1PI) have been measured as markers of macrophage and neutrophil activation, respectively, in serial plasma samples from 27 patients with acute pancreatitis. Levels of TNF-α did not support the possibility of excessive macrophage activation, but raised levels of E-α1PI in patients with either the mild or severe form of the illness indicated the activation of neutrophils. Whether this is a consequence of the illness or is a contributory factor in the pathogenesis is not clear. © 1991.

引用

页码：12 / 16

页数：5

共 23 条

[1] CIRCULATING HUMAN-LEUKOCYTE ELASTASE IN PATIENTS WITH INFLAMMATORY BOWEL-DISEASE [J].