STABILITY OF AMITRIPTYLINE HYDROCHLORIDE IN A COMMERCIAL AQUEOUS-SOLUTION

被引：4

作者：

ROMAN, R

COHEN, EM

CHRISTY, ME

HAGERMAN, WB

机构：

[1] Pharmacy Research and Development Department, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 10期

关键词：

Amitriptyline hydrochloride—stability; commercial aqueous solutions; high‐performance liquid chromatography; Anti‐depressants—amitriptyline hydrochloride; stability; High‐performance liquid chromatography—analysis; amitriptyline hydrochloride in commercial aqueous solutions;

D O I：

10.1002/jps.2600681039

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A commercial amitriptyline hydrochloride solution was stored at 80° for up to 3 months. High‐performance liquid chromatography showed no evidence of amitriptyline hydrochloride degradation. The method also indicated that two reported degradates, 3‐(propa‐1,3‐dienyl)‐1,2:4,5‐dibenzocyclohepta‐1,4‐diene and dibenzosuberone, were present at levels less than 0.1% (the detection limit of the method) under the storage conditions. The stability of the commercial solutions is attributed to their relatively low ratio of headspace oxygen to amitriptyline hydrochloride. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1329 / 1330

页数：2

共 5 条

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[4]

1975, US PHARMACOPEIA, P28

[5]

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