ANTIFUNGAL AGENTS .6. IN-VITRO ANTIFUNGAL ACTIVITIES OF HALOBENZOYL ESTERS OF CIS-[2-(1,1'-BIPHENYL-4-YL)-2-(1H-IMIDAZAOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]CARBINOLS AND TRANS-[2-(1,1'-BIPHENYL-4-YL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]CARBINOLS

The synthesis and the in vitro antifungal activities against Candida albicans and Candida spp of a number of halobenzoyl esters of cis- and trans-[2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]carbinols is reported. Some new imidazoles were found more active than ketoconazole and sometimes as potent as bifonazole against Candida albicans. All derivatives were found scarcely active against Candida spp.