A Comparative Double-Blind Randomized Clinical Trial Study on Effect of Various Analgesic Intravenous Injections on Propofol Post-injection Pain in Patients Undergoing Elective Surgery

Propofol is an intravenous anesthetic widely used in outpatient and short-duration surgeries for rapid recovery. Pain during injection may cause discomfort in some patients. Several medications have been suggested that reduce the severity of pain during propofol injection. The present study aimed to compare the effect of intravenous injection of paracetamol, dexamethasone, pethidine, lidocaine, and ketamine on propofol post-injection pain in patients undergoing elective surgery, following a double-blind randomized clinical trial on 306 patients aged from 18 to 65 who were candidates for elective surgery. Patients were divided into six groups each group consisted of 51 individuals. Mean age of participants in this study was 31.9 +/- 9.5 out of which 209 (68.3%) were males and 97 (31.7%) were females. Lidocaine and paracetamol revealed the highest pain-free parameters among other groups. Pain severity was also less in lidocaine and dexamethasone groups than other groups. Finally, lidocaine was seen to be the most efficacious analgesic in reducing pain from propofol injection and could be safely advised for propofol-induced pain relieve.