NADP-LINKED ISOZYMES ARE THE MAJOR FORMS OF ISOCITRATE DEHYDROGENASE IN MOUSE TYPE-1-LIKE ASTROCYTES

被引：8

作者：

JUURLINK, BHJ

机构：

[1] Department of Anatomy University of Saskatchewan, Saskatoon

来源：

LIFE SCIENCES | 1993年 / 52卷 / 13期

关键词：

D O I：

10.1016/0024-3205(93)90429-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The activities of cytosolic NADP-linked and mitochondrial NADP- and NAD-linked isocitrate dehydrogenases were examined in three-week-old mouse astroglial cultures. The respective activities were found to be 57 +/- 7, 101 +/- 3 and 8 +/- 1 nmoles NAD(P)+ reduced per mg protein per min. Both dibutyryl cyclic AMP and cortisol caused a significant increase in the activity of the mitochondrial as well as cytosolic NADP-linked isozymes.

引用

页码：1087 / 1090

页数：4