PREVENTION OF SELENITE CATARACT BY VITAMIN-C

被引：88

作者：

DEVAMANOHARAN, PS ^{[1
]}

HENEIN, M ^{[1
]}

MORRIS, S ^{[1
]}

RAMACHANDRAN, S ^{[1
]}

RICHARDS, RD ^{[1
]}

VARMA, SD ^{[1
]}

机构：

[1] UNIV MARYLAND, SCH MED, DEPT OPHTHALMOL, 10 S PINE ST, BALTIMORE, MD 21201 USA

来源：

EXPERIMENTAL EYE RESEARCH | 1991年 / 52卷 / 05期

关键词：

ASCORBATE; VITAMIN-C; CATARACT PREVENTION; SELENITE; OXIDATIVE STRESS;

D O I：

10.1016/0014-4835(91)90057-L

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Studies have been conducted to determine the efficacy of vitamin C in the prevention of cataracts induced by selenite. Administration of the latter to rat pups results in the development of advanced cataracts within 5 days. Treatment with ascorbate had a significant preventive effect. The observations indicate that selenite cataract is due to an oxidative stress to the lens. In addition, the findings are in conformity with our view that ascorbate functions as an anticataractogenic substance. © 1991.

引用

页码：563 / 568

页数：6

共 29 条

[1]

Bessey OA, 1933, J BIOL CHEM, V103, P687

[2]

BHUYAN DK, 1977, INVEST OPHTH VIS SCI, V16, P15

[3]

BHUYAN KC, 1981, IRCS MED SCI-BIOCHEM, V9, P194

[4]

BHUYAN KC, 1981, IRCS MED SCI-BIOCHEM, V9, P195

[5] KINETICS AND MECHANISM FOR THE OXIDATION OF ASCORBIC-ACID ASCORBATE BY HO2 O2- RADICALS - A PULSE-RADIOLYSIS AND STOPPED-FLOW PHOTOLIS STUDY [J].

CABELLI, DE ;

BIELSKI, BHJ .

JOURNAL OF PHYSICAL CHEMISTRY, 1983, 87 (10) :1809-1812

[6]

CHANDRA DB, 1986, INT J VITAM NUTR RES, V56, P165

[7] STATE OF SULFHYDRYL IN SELENITE CATARACT [J].

DAVID, LL ;

SHEARER, TR .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1984, 74 (01) :109-115

[8]

DAVSON H, 1962, PHYSL EYE, P90

[9] TISSUE SULFHYDRYL GROUPS [J].

ELLMAN, GL .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1959, 82 (01) :70-77

[10]

FARHATAZIZ, 1977, WASHINGTON DC PUBLIC, V59

← 1 2 3 →