MINOXIDIL SPECIFICALLY DECREASES THE EXPRESSION OF LYSINE HYDROXYLASE IN CULTURED HUMAN SKIN FIBROBLASTS

被引：24
作者：
HAUTALA, T
HEIKKINEN, J
KIVIRIKKO, KI
MYLLYLA, R
机构：
[1] UNIV OULU, BIOCTR, COLLAGEN RES UNIT, KAJAANINTIE 52A, SF-90220 OULU, FINLAND
[2] UNIV OULU, DEPT MED BIOCHEM, SF-90220 OULU, FINLAND
来源：
BIOCHEMICAL JOURNAL | 1992年 / 283卷
关键词：
D O I：
10.1042/bj2830051
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The level of lysine hydroxylase protein and the levels of the mRNAs for lysine hydroxylase and the alpha- and beta-subunits of proline 4-hydroxylase were measured in cultured human skin fibroblasts treated with 1 mM-minoxidil. The data demonstrate that minoxidil decreases the amount of lysine hydroxylase protein, this being due to a decrease in the level of lysine hydroxylase mRNA. The effect of minoxidil appears to be highly specific, as no changes were observed in the amounts of mRNAs for the alpha- and beta-subunits of proline 4-hydroxylase.
引用
收藏
页码：51 / 54
页数：4
相关论文
共 24 条
[1]   CORRELATION OF THE STEADY-STATE RNA LEVELS AMONG THE ALPHA-SUBUNIT OF PROLYL 4-HYDROXYLASE AND THE ALPHA-1 AND ALPHA-2 CHAINS OF TYPE-I COLLAGEN DURING GROWTH OF CHICKEN-EMBRYO TENDON FIBROBLASTS [J].
BASSUK, JA ;
BERG, RA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 174 (01) :169-175
[2]   PROLYL 4-HYDROXYLASE - MOLECULAR-CLONING AND THE PRIMARY STRUCTURE OF THE ALPHA-SUBUNIT FROM CHICKEN-EMBRYO [J].
BASSUK, JA ;
KAO, WWY ;
HERZER, P ;
KEDERSHA, NL ;
SEYER, J ;
DEMARTINO, JA ;
DAUGHERTY, BL ;
MARK, GE ;
BERG, RA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (19) :7382-7386
[3]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[4]  
CHENG SY, 1987, J BIOL CHEM, V262, P11221
[5]  
DHAWAN J, 1991, J BIOL CHEM, V266, P8470
[6]  
HAMALAINEN L, 1985, J BIOL CHEM, V260, P720
[7]   MOLECULAR-CLONING OF THE ALPHA-SUBUNIT OF HUMAN PROLYL 4-HYDROXYLASE - THE COMPLETE CDNA-DERIVED AMINO-ACID SEQUENCE AND EVIDENCE FOR ALTERNATIVE SPLICING OF RNA TRANSCRIPTS [J].
HELAAKOSKI, T ;
VUORI, K ;
MYLLYLA, R ;
KIVIRIKKO, KI ;
PIHLAJANIEMI, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (12) :4392-4396
[8]  
HELAAKOSKI T, 1990, J BIOL CHEM, V265, P11413
[9]   ISOLATION OF CDNA CLONES AND GENOMIC DNA CLONES OF BETA-SUBUNIT OF CHICKEN PROLYL 4-HYDROXYLASE [J].
KAO, WWY ;
NAKAZAWA, M ;
AIDA, T ;
EVERSON, WV ;
KAO, CWC ;
SEYER, JM ;
HUGHES, SH .
CONNECTIVE TISSUE RESEARCH, 1988, 18 (03) :157-174
[10]   POSTTRANSLATIONAL PROCESSING OF PROCOLLAGENS [J].
KIVIRIKKO, KI ;
MYLLYLA, R .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1985, 460 :187-201
123