INHIBITION OF HIV-1 INTEGRATION PROTEIN BY AURINTRICARBOXYLIC ACID MONOMERS, MONOMER ANALOGS, AND POLYMER FRACTIONS

被引：82

作者：

CUSHMAN, M ^{[1
]}

SHERMAN, P ^{[1
]}

机构：

[1] BURROUGHS WELLCOME CO, DIV EXPTL THERAPY, RES TRIANGLE PK, NC 27709 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 185卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)80958-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several aurintricarboxylic acid (ATA) monomers, monomer analogs, and polymer fractions have been tested as inhibitors of HIV-1 integration protein (IN). Both of the ATA monomers and all of the ATA polymer fractions inhibited a selective DNA cleavage reaction catalyzed by IN. The ATA monomer analogs were inactive or had low activity. The activities of the substances as inhibitors of HIV IN correlated in a positive way with their activities as inhibitors of the cytopathic effect of HIV-1 in CEM and HIV-2 in MT4 cells. These results suggest that inhibition of HIV IN may contribute to the antiviral activity of the ATA monomers and monomer analogs in cell culture. © 1992 Academic Press, Inc.

引用

页码：85 / 90

页数：6

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