Tritium Labeling of Bioorganic Compounds by Isotope Exchange

Procedures for preparing labeled compounds by liquid-and solid-phase methods using gaseous tritium and by isotope exchange with tritium water are considered as different manifestations of a common complex of processes occurring in the presence of tritium, a substrate, and a catalyst. The studies performed allow purposeful optimization of the conditions of tritium labeling of practically any biologically active substance, which makes possible more detailed investigation of the functioning of living objects.