THE EFFECT OF INSULIN AND ALDOSE REDUCTASE INHIBITION ON THE PHOSPHATE-METABOLISM OF STREPTOZOTOCIN-DIABETIC RAT LENS

被引：10
|
作者：
CHENG, HM
YOSHIDA, A
XIONG, H
GONZALEZ, RG
机构：
[1] HARVARD UNIV,MASSACHUSETTS EYE & EAR INFIRM,SCH MED,BOSTON,MA 02114
[2] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT RADIOL,BOSTON,MA 02114
来源：
EXPERIMENTAL EYE RESEARCH | 1991年 / 53卷 / 06期
关键词：
SORBITOL-3-PHOSPHATE; FRUCTOSE-3-PHOSPHATE; P-31]NMR; STREPTOZOTOCIN-DIABETES; RAT LENS; INSULIN; ALDOSE REDUCTASE INHIBITION;
D O I：
10.1016/0014-4835(91)90117-W
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Sorbitol-3-phosphate (S3P) and fructose-3-phosphate (F3P) are novel phosphorus compounds recently discovered and identified in the crystalline lens as well as other tissues. These phosphates increased with diabetes progression in streptozotocin-diabetic rat lenses. Treatment of these rats with an orally administered aldose reductase inhibitor eliminated S3P and intramuscularly injected insulin obliterated F3P. These results indicate that enzymes catalyzing S3P and F3P formation co-activate with aldose reductase activation and hyperglycemia, respectively. © 1991.
引用
收藏
页码：805 / 808
页数：4
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