CYTOKINE-ACTIVATED HUMAN MESANGIAL CELLS GENERATE THE NEUTROPHIL CHEMOATTRACTANT, INTERLEUKIN-8

被引：82

作者：

BROWN, Z

STRIETER, RM

CHENSUE, SW

CESKA, M

LINDLEY, I

NEILD, GH

KUNKEL, SL

WESTWICK, J

机构：

[1] UNIV BATH,DEPT PHARMACOL,CLAVERTON DOWN,BATH BA2 7AY,AVON,ENGLAND

[2] UNIV COLL & MIDDLESEX SCH MED,INST UROL,DEPT RENAL MED,LONDON,ENGLAND

[3] UNIV MICHIGAN,DEPT PATHOL,ANN ARBOR,MI 48109

[4] SANDOZ GMBH,A-1235 VIENNA,AUSTRIA

来源：

KIDNEY INTERNATIONAL | 1991年 / 40卷 / 01期

关键词：

D O I：

10.1038/ki.1991.184

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Human mesangial cells (MC) in culture, when stimulated by interleukin 1-alpha(IL-1-alpha) or tumour necrosis factor (TNF-alpha), but not with lipopolysaccharide (LPS), express interleukin 8 (IL-8) mRNA, and both cell associated and extracellular IL-8. Dexamethasone treatment of mesangial cells induced partial inhibition of the release of extracellular IL-8, while cell-associated IL-8 and IL-8 mRNA were not significantly altered. We propose that the mesangial cell has a direct role in the initiation and propagation of inflammatory events within the glomerulus via the generation of the chemotactic cytokine IL-8.

引用

页码：86 / 90

页数：5

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