ANTIOXIDANT ENZYMES IN THE AGING HUMAN RETINAL-PIGMENT EPITHELIUM

被引：161

作者：

LILES, MR

NEWSOME, DA

OLIVER, PD

机构：

[1] TOURO INFIRM,SENSORY & ELECTROPHYSIOL RES UNIT,1401 FOUCHER ST,NEW ORLEANS,LA 70115

[2] TULANE UNIV,SCH MED,DEPT OPHTHALMOL,NEW ORLEANS,LA 70112

[3] TULANE UNIV,SCH MED,DEPT ANAT,NEW ORLEANS,LA 70112

来源：

ARCHIVES OF OPHTHALMOLOGY | 1991年 / 109卷 / 09期

关键词：

D O I：

10.1001/archopht.1991.01080090111033

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The antioxidant enzymes catalase and superoxide dismutase have integral roles in controlling reactive oxygen radicals that can harm cells. In the present study, we quantitated catalase activity in retinal pigment epithelium, retina, iris, and vitreous from human donors. To our knowledge, our results represent the first quantitation of catalase activity in human retinal pigment epithelium and show six-fold greater catalase activity in retinal pigment epithelium than in other ocular tissues analyzed (P < .0001). To investigate whether aging or macular degeneration affects retinal pigment epithelium catalase or superoxide dismutase activities, we measured enzyme levels in retinal pigment epithelium from donors 50 to 90 years of age with and without evidence of macular degeneration. Superoxide dismutase activity showed no significant correlations with aging or macular degeneration, while catalase activity decreased with age (P < .02) and macular degeneration (P < .05) in both macular and peripheral retinal pigment epithelium.

引用

页码：1285 / 1288

页数：4

共 40 条

[1]

ALDER VA, 1983, INVEST OPHTH VIS SCI, V24, P30

[2] LIPID-PEROXIDATION AND RETINAL DEGENERATION [J].