PSYCHOSOCIAL GROWTH FAILURE - A POSITIVE RESPONSE TO GROWTH-HORMONE AND PLACEBO

被引：12

作者：

BOULTON, TJC ^{[1
]}

SMITH, R ^{[1
]}

SINGLE, T ^{[1
]}

机构：

[1] UNIV NEWCASTLE, FAC MED, NEWCASTLE, NSW 2308, AUSTRALIA

来源：

ACTA PAEDIATRICA | 1992年 / 81卷 / 04期

关键词：

EMOTION; GROWTH FAILURE; GROWTH HORMONE TREATMENT; NUTRITION;

D O I：

10.1111/j.1651-2227.1992.tb12235.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Seven children were diagnosed as having an emotional cause for growth failure. Pretreatment growth hormone secretion profiles during sleep were analysed using PULSAR. Mean (+/- SD) growth hormone concentration was 10.9 (4.4) mU/1, mean peak 19.6 (6.7) mU/1 and the peak-to-peak interval 147 (108) min. Mean (SEM) IGF-1 was 1.08 (0.31). The seven children received a six-month course of recombinant growth hormone in a double-blind, crossover study using a dose of 1.2 U/kg/week (28 U/m2/week). Daily placebo injections were given for the other six-month epoch, with a one month washout period. The mean (SEM) growth velocity SD score after growth hormone administration was + 4.66 (1.88) and after placebo - 0.60 (0.69), each value being greater than the pretreatment value of - 2.32 (0.122) (p < 0.0001 on analysis of variance). The change in IGF-1 during growth hormone treatment was not significant. No significant changes in food energy or protein intake occurred.

引用

页码：322 / 325

页数：4

共 39 条

[11] RELATIONSHIP BETWEEN SLEEP STAGE-IV DEFICIT AND REVERSIBLE HGH DEFICIENCY IN PSYCHO-SOCIAL DWARFISM [J].

GUILHAUME, A ;

BENOIT, O ;

GOURMELEN, M ;

RICHARDET, JM .

PEDIATRIC RESEARCH, 1982, 16 (04) :299-303

[12]

HALL CA, 1986, CLIN BIOCHEM REV, V7, P87

[13]

HAMILL PVV, 1985, DH W PHS781650 PUBL

[14] SOMATOMEDIN-C RESPONSE TO GROWTH-HORMONE IN PSYCHOSOCIAL GROWTH-RETARDATION [J].

HOLMES, NE ;

BLETHEN, SL ;

WELDON, VV .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1984, 288 (02) :86-88

[15]

Hopwood N.J., 1979, CHILD ABUSE NEGLECT, V3, P439

[16]

HOWELLS JG, 1967, FAMILY RELATIONS IND

[17] PITUITARY FUNCTION IN DEPRIVATION SYNDROME [J].

KRIEGER, I ;

MELLINGER, RC .

JOURNAL OF PEDIATRICS, 1971, 79 (02) :216-+

[18]

Lang M., 1978, CHILDRENS DEPRESSION

[19]

MACCARTHY D, 1981, SCI F PAEDIATRICS, P54

[20] FOOD-INTAKE DURING CHILDHOOD - PERCENTILES OF FOOD-ENERGY, MACRONUTRIENT AND SELECTED MICRONUTRIENTS FROM INFANCY TO 8 YEARS OF AGE [J].

MAGAREY, A ;

BOULTON, TJC .

MEDICAL JOURNAL OF AUSTRALIA, 1987, 147 (03) :124-127

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