HUNTINGTONS-DISEASE AND ITS ANIMAL-MODEL - ALTERATIONS IN KAINIC ACID BINDING

被引：39
作者：
BEAUMONT, K
MAURIN, Y
REISINE, TD
FIELDS, JZ
SPOKES, E
BIRD, ED
YAMAMURA, HI
机构：
[1] UNIV ARIZONA,HLTH SCI CTR,DEPT PHARMACOL,TUCSON,AZ 85724
[2] ADDENBROOKES HOSP,CAMBRIDGE CB2 2QQ,ENGLAND
来源：
LIFE SCIENCES | 1979年 / 24卷 / 09期
关键词：
D O I：
10.1016/0024-3205(79)90365-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The density of 3H-kainic acid (KA) binding was determined in several regions of Huntington's Diseased (HD) and control human brains. 3H-Kainic acid binding was significantly reduced by 55% in the caudate nucleus and by 53% in the putamen of HD brains. In addition, 3H-KA binding was determined in rat striatum at various intervals following lesion with KA, a procedure which produces an animal model of HD. After KA lesion, 3H-KA binding in the rat striatum underwent a slow reduction, reaching 25% of control after 6 weeks. Several properties of 3H-KA binding to rat brain membranes were also investigated, including inhibition by ions, regional distribution and displacement by various compounds. The findings confirm the validity of the KA-lesioned model for HD and suggest a post-synaptic location for kainic acid receptors in the striatum. © 1979.
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页码：809 / 816
页数：8
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