DIMETHYLNITROSAMINE AND HYDRAZINE SULFATE

The toxicological Interaction between hydrazine sulfate and dimethylnitrosamine (DMN) was investigated for two reasons; the possible coincident exposure to chemicals in both industrial and military facilities, and because hydrazine and its derivatives may effect enzymatic oxidation oí DMN with alteration in its toxicologic and pathologic manifestations. No evidence of significant biologic interaction was observed when possible synergism or antagonism of the two compounds was investigated in random-bred Swiss mice. In DMN-treated animals given doses approaching LD50, endothelial necrosis of central and sub-lobular veins was seen with extrusion of necrotic hepatic tissue into the hepatic venous drainage system. Intrapulmonary bodies possibly derived from intrahepatic tissue are described. © 1968 Taylor & Francis Group, LLC.