THE APPLICATION OF RECEPTOR THEORY TO RECEPTOR-BINDING AND ENZYME-BINDING ONCOLOGIC RADIOPHARMACEUTICALS

被引：48
作者：
ECKELMAN, WC
机构：
[1] PET Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892
来源：
NUCLEAR MEDICINE AND BIOLOGY | 1994年 / 21卷 / 05期
关键词：
D O I：
10.1016/0969-8051(94)90047-7
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The successful imaging of tumor biochemistry using a receptor binding radiotracer is related to the affinity constant and the receptor concentration. The target to nontarget ratio can be predicted by steady state equations using in vitro data, although this is a necessary but not sufficient upper limit. The prediction of the sensitivity of the radiopharmaceutical to changes in the tumor biochemistry is not possible with this evaluation.
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页码：759 / 769
页数：11
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