CYTOTOXIC ACTIVITY OF TAXOL IN PRIMARY CULTURES OF TUMOR-CELLS FROM PATIENTS IS PARTLY MEDIATED BY CREMOPHOR EL

被引：49

作者：

NYGREN, P

CSOKA, K

JONSSON, B

FRIDBORG, H

BERGH, J

HAGBERG, H

GLIMELIUS, B

BRODIN, O

THOLANDER, B

KREUGER, A

LONNERHOLM, G

JAKOBSSON, A

OLSEN, L

KRISTENSEN, J

LARSSON, R

机构：

[1] UNIV UPPSALA HOSP, DIV CLIN PHARMACOL, S-75185 UPPSALA, SWEDEN

[2] UNIV UPPSALA HOSP, DEPT GYNECOL ONCOL, S-75185 UPPSALA, SWEDEN

[3] UNIV UPPSALA HOSP, DEPT PEDIAT, S-75185 UPPSALA, SWEDEN

[4] UNIV UPPSALA HOSP, DEPT PEDIAT SURG, S-75185 UPPSALA, SWEDEN

[5] UNIV UPPSALA HOSP, DEPT INTERNAL MED, S-75185 UPPSALA, SWEDEN

来源：

BRITISH JOURNAL OF CANCER | 1995年 / 71卷 / 03期

关键词：

TAXOL; CREMOPHOR EL; PRIMARY CULTURE; TUMOR CELL;

D O I：

10.1038/bjc.1995.97

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In patient tumour samples the activity in vitro of Taxol corresponded fairly well to the known clinical activity and Taxol showed low cross-resistance to standard cytotoxic drugs. However, the Taxol solvent Cremophor EL-ethanol was considerably active alone, whereas paclitaxel formulated in ethanol was less active. Taxol thus seems to contain two components active against patient tumour cells in vitro.

引用

页码：478 / 481

页数：4

共 27 条

[1] ALTERED PLASMA-MEMBRANE ULTRASTRUCTURE IN MULTIDRUG-RESISTANT CELLS [J].