BIOAVAILABILITY PREDICTION OF AMINO-ACIDS AND PEPTIDES IN NUTRITIVE MIXTURES BY SEPARATION ON NONPOLAR STATIONARY PHASES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND DIRECT UV DETECTION AT 210 NM

被引:10
作者
FIALAIRE, A [1 ]
POSTAIRE, E [1 ]
PROGNON, R [1 ]
PRADEAU, D [1 ]
机构
[1] CENT PHARM PARIS HOSP,QUAL CONTROL LAB,F-75005 PARIS,FRANCE
来源
JOURNAL OF LIQUID CHROMATOGRAPHY | 1993年 / 16卷 / 14期
关键词
D O I
10.1080/10826079308019629
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A reversed phase high-performance liquid chromatography method was developed to separate amino acids contents in total parenteral nutrition solution and peptides in enteral mixtures. Retention is attributed to hydrophobic interactions between the solutes and the hydrocarbonaceous functions covalently bound to the stationary phase surface. Consequently, the analytes were eluted in the order of their increasing hydrophobicity. The mixtures were analyzed by using gradient elution with increasing content and monitoring the column efluent at 210 nm.
引用
收藏
页码:3003 / 3015
页数:13
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