SOLID-PHASE PEPTIDE-SYNTHESIS ON HYDROPHILIC SUPPORTS .2. STUDIES USING PERLOZA BEADED CELLULOSE

被引：0

作者：

ENGLEBRETSEN, DR ^{[1
]}

HARDING, DRK ^{[1
]}

机构：

[1] MASSEY UNIV,SEPARAT SCI UNIT,PALMERSTON NORTH,NEW ZEALAND

来源：

INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH | 1992年 / 40卷 / 06期

关键词：

ACID AND BASE LABILE LINKERS; BORON TRIFLUORIDE CLEAVAGE; T-BUTYLOXYCARBONYL; HYDROPHILIC AMINOPROPYL BEADED CELLULOSE; 9-FLUORENYLMETHYLOXYCARBONYL; SOLID PHASE PEPTIDE SYNTHESIS;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Beaded cellulose (Perloza) was modified with acrylonitrile followed by reduction with diborane to give a functionalised support containing aminopropyl groups. This spacer arm was then further extended with a glycolamido or an Fmoc-amino acid-4-oxymethylphenoxyacetyl moiety. A number of peptides, including the Merrifield test peptide leucyl-alanyl-glycyl-valine, leucine-enkephalin, Acyl Carrier Protein (65-74), angiotensin I and II, ACTH(4-11) and LHRH were synthesised on the aminopropyl beaded cellulose support using modified t-butyloxycarbonyl (Boc) or fluorenylmethoxycarbonyl (Fmoc) synthesis protocols. The peptides were cleaved from the support and further purified.

引用

页码：487 / 496

页数：10

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