SOLID-PHASE PEPTIDE-SYNTHESIS ON HYDROPHILIC SUPPORTS .2. STUDIES USING PERLOZA BEADED CELLULOSE

被引：0
作者：
ENGLEBRETSEN, DR [1 ]
HARDING, DRK [1 ]
机构：
[1] MASSEY UNIV,SEPARAT SCI UNIT,PALMERSTON NORTH,NEW ZEALAND
来源：
INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH | 1992年 / 40卷 / 06期
关键词：
ACID AND BASE LABILE LINKERS; BORON TRIFLUORIDE CLEAVAGE; T-BUTYLOXYCARBONYL; HYDROPHILIC AMINOPROPYL BEADED CELLULOSE; 9-FLUORENYLMETHYLOXYCARBONYL; SOLID PHASE PEPTIDE SYNTHESIS;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Beaded cellulose (Perloza) was modified with acrylonitrile followed by reduction with diborane to give a functionalised support containing aminopropyl groups. This spacer arm was then further extended with a glycolamido or an Fmoc-amino acid-4-oxymethylphenoxyacetyl moiety. A number of peptides, including the Merrifield test peptide leucyl-alanyl-glycyl-valine, leucine-enkephalin, Acyl Carrier Protein (65-74), angiotensin I and II, ACTH(4-11) and LHRH were synthesised on the aminopropyl beaded cellulose support using modified t-butyloxycarbonyl (Boc) or fluorenylmethoxycarbonyl (Fmoc) synthesis protocols. The peptides were cleaved from the support and further purified.
引用
收藏
页码：487 / 496
页数：10
相关论文
共 50 条
  • [21] Solid-phase peptide synthesis using Nα-trityl-amino acids
    de la Torre, BG
    Marcos, MA
    Eritja, R
    Albericio, F
    LETTERS IN PEPTIDE SCIENCE, 2001, 8 (06): : 331 - 338
  • [22] Solid-phase peptide synthesis using Nα-trityl-amino acids
    Beatriz G. de la Torre
    Miguel A. Marcos
    Ramon Eritja
    Fernando Albericio
    Letters in Peptide Science, 2001, 8 : 331 - 338
  • [23] SYNTHESIS OF GLYCOPEPTIDE DERIVATIVES OF PEPTIDE T ON A SOLID-PHASE USING AN ALLYLIC LINKAGE
    KOSCH, W
    MARZ, J
    KUNZ, H
    REACTIVE POLYMERS, 1994, 22 (03): : 181 - 194
  • [24] Synthesis of a new chiral peptide analogue of DNA using ornithine subunits and solid-phase peptide synthesis methodologies
    Lioy, E
    Kessler, H
    LIEBIGS ANNALEN, 1996, (02): : 201 - 204
  • [25] Revisiting NO2 as Protecting Group of Arginine in Solid-Phase Peptide Synthesis
    Alhassan, Mahama
    Kumar, Ashish
    Lopez, John
    Albericio, Fernando
    de la Torre, Beatriz G.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (12) : 1 - 12
  • [26] AUTOMATIC SYNCHROM SYSTEM FOR SOLID-PHASE PEPTIDE-SYNTHESIS AND LIQUID COLUMN CHROMATOGRAPHY .1. PRINCIPLES OF DESIGN AND STRUCTURAL CONSTITUENTS
    BARU, MB
    CHERSKII, VV
    DANILOV, AV
    MOSHNIKOV, SA
    MUSTAEVA, LG
    BIOORGANICHESKAYA KHIMIYA, 1995, 21 (07): : 498 - 505
  • [27] 2-Methyltetrahydrofuran and cyclopentyl methyl ether for green solid-phase peptide synthesis
    Yahya E. Jad
    Gerardo A. Acosta
    Sherine N. Khattab
    Beatriz G. de la Torre
    Thavendran Govender
    Hendrik G. Kruger
    Ayman El-Faham
    Fernando Albericio
    Amino Acids, 2016, 48 : 419 - 426
  • [28] 2-Methyltetrahydrofuran and cyclopentyl methyl ether for green solid-phase peptide synthesis
    Jad, Yahya E.
    Acosta, Gerardo A.
    Khattab, Sherine N.
    de la Torre, Beatriz G.
    Govender, Thavendran
    Kruger, Hendrik G.
    El-Faham, Ayman
    Albericio, Fernando
    AMINO ACIDS, 2016, 48 (02) : 419 - 426
  • [29] N-2-(2,4-DINITROPHENYL)ETHYLOXYCARBONYL-AMINO ACIDS, NEW BASE LABILE PROTECTED DERIVATIVES SUITABLE FOR SOLID-PHASE PEPTIDE-SYNTHESIS
    ACEDO, M
    ALBERICIO, F
    ERITJA, R
    TETRAHEDRON LETTERS, 1992, 33 (34) : 4989 - 4992
  • [30] Solid-phase peptide synthesis using acetonitrile as a solvent in combination with PEG-based resins
    Acosta, Gerardo A.
    del Fresno, Montserrat
    Paradis-Bas, Marta
    Rigau-DeLlobet, Maria
    Cote, Simon
    Royo, Miriam
    Albericio, Fernando
    JOURNAL OF PEPTIDE SCIENCE, 2009, 15 (10) : 629 - 633
12345