SOLID-PHASE PEPTIDE-SYNTHESIS ON HYDROPHILIC SUPPORTS .2. STUDIES USING PERLOZA BEADED CELLULOSE

被引：0
|
作者：
ENGLEBRETSEN, DR [1 ]
HARDING, DRK [1 ]
机构：
[1] MASSEY UNIV,SEPARAT SCI UNIT,PALMERSTON NORTH,NEW ZEALAND
来源：
INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH | 1992年 / 40卷 / 06期
关键词：
ACID AND BASE LABILE LINKERS; BORON TRIFLUORIDE CLEAVAGE; T-BUTYLOXYCARBONYL; HYDROPHILIC AMINOPROPYL BEADED CELLULOSE; 9-FLUORENYLMETHYLOXYCARBONYL; SOLID PHASE PEPTIDE SYNTHESIS;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Beaded cellulose (Perloza) was modified with acrylonitrile followed by reduction with diborane to give a functionalised support containing aminopropyl groups. This spacer arm was then further extended with a glycolamido or an Fmoc-amino acid-4-oxymethylphenoxyacetyl moiety. A number of peptides, including the Merrifield test peptide leucyl-alanyl-glycyl-valine, leucine-enkephalin, Acyl Carrier Protein (65-74), angiotensin I and II, ACTH(4-11) and LHRH were synthesised on the aminopropyl beaded cellulose support using modified t-butyloxycarbonyl (Boc) or fluorenylmethoxycarbonyl (Fmoc) synthesis protocols. The peptides were cleaved from the support and further purified.
引用
收藏
页码：487 / 496
页数：10
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