SYSTEMIC DELIVERY OF POLYPEPTIDE DRUGS THROUGH OCULAR ROUTE

被引：18
作者：
CHIOU, GCY
机构：
[1] Institute of Ocular Pharmacology, Department of Medical Pharmacology and Toxicology, Texas A&M University Health Science Center, College Station, Texas
来源：
JOURNAL OF OCULAR PHARMACOLOGY | 1994年 / 10卷 / 01期
关键词：
D O I：
10.1089/jop.1994.10.93
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Because of rapid developments in biotechnology, numerous peptides are now available for clinical treatment of various diseases. In order to avoid parenteral injections, alternative routes of drug administration have been investigated. Among them, the ocular route seemed to be the most feasible one because a) it could deliver precise doses of drugs just like injections; b) it was much easier and less expensive to administer eyedrops than an injection; c) the rate of systemic absorption through the ocular route was as fast as an injection; d) eye tissues were much less sensitive to the development of immunological reactions than other tissues; e) the drug absorbed via the ocular route would avoid the first passage through hepatic circulation to reach the sites of action before liver metabolism; and f) no tolerance and ocular side effects could be detected after long-term (three months) daily administration of insulin eyedrops.
引用
收藏
页码：93 / 99
页数：7
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共 35 条
  • [1] Chiou G.C.Y., Systemic delivery of polypeptide dmgs through ocular route, Ann. Rev. Pharmacol. Toxicol., 31, pp. 457-467, (1991)
  • [2] Yamasaki Y., Shichiri M., Kawamori R., Kikuchi M., Yagi T., Arai S., Tohdo R., Hakui N., Oji N., Abe H., The effectiveness of rectal administration of insulin suppository on normal and diabetic subjects, Diabetes Care, 4, pp. 454-458, (1981)
  • [3] Fisher N.F., The absorption of insulin from the intestine, vagina and scrota sac, Am. J. Phvsiol., 67, pp. 65-71, (1923)
  • [4] Anders R., Maride H.P., Schurr W., Ziegler R., Buccal absorption of protirelin: An effective way to stimulate fhyrotropin and prolactin, J. Pharm. Sci., 72, pp. 1481-1483, (1983)
  • [5] Moses A.C., Gordon G.S., Carey M.C., Flier J.S., Insulin administered intranasally as an insulin-bile salt aerosol, effectiveness and reproducibility in normal and diabetic subjects, Diabetes, 32, pp. 1040-1047, (1983)
  • [6] Hirai S., Ikenaga T., Matsuzawa T., Nasal absorption of insulin in dogs, Diabetes, 27, pp. 296-299, (1978)
  • [7] Salzman R., Manson J.E., Griffing G.T., Kimmerle R., Ruderman N., Phil D., McCall A., Stoltz E.F., Mullin C., Small D., Armstrong J., Melby J.C., Intranasal aerosolized insulin
  • [8] mixed-meal studies and long-term use in type I diabetes, N. Eng. J. Med., 312, pp. 1078-1084, (1985)
  • [9] Wigley F.M., Londono J.H., Wood S.H., Shipp J.C., Waldman R.H., Insulin across respiratory mucosae by aerosol delivery, Diabetes, 20, pp. 552-556, (1971)
  • [10] Kari B., Control of blood glucose levels of alloxan-diabetic rabbits by iontophoresis of insulin, Diabetes, 35, pp. 217-221, (1986)
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