EXAMINATION OF DES-TYROSINE1-GAMMA-ENDORPHIN ACTIVITY AT H-3-SPIROPERIDOL BINDING-SITES IN RAT-BRAIN

被引：42
作者：
PEDIGO, NW [1 ]
LING, NC [1 ]
REISINE, TD [1 ]
YAMAMURA, HI [1 ]
机构：
[1] SALK INST,NEUROENDOCRINOL LAB,LA JOLLA,CA 92112
来源：
LIFE SCIENCES | 1979年 / 24卷 / 18期
关键词：
D O I：
10.1016/0024-3205(79)90247-9
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Des-tyrosine1-γ-endorphin (DTγE, β-LPH 62-77) was tested for its ability to affect the binding of 3H-spiroperidol in rat corpus striatum, frontal cortex and nucleus accumbens-olfactory tubercle. 3H-Spiroperidol binds with high affinity and specificity to neuroleptic receptors in brain tissue. The inability of DTγE to inhibit specific 3H-spiroperidol binding reported here suggests that DTγE is not acting at the neuroleptic receptor labeled by 3H-spiroperidol in these regions of rat brain. © 1979.
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页码：1645 / 1649
页数：5
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