FACTORS AFFECTING SHORT-TERM AND LONG-TERM STABILITIES OF PROTEINS

被引：163

作者：

ARAKAWA, T ^{[1
]}

PRESTRELSKI, SJ ^{[1
]}

KENNEY, WC ^{[1
]}

CARPENTER, JF ^{[1
]}

机构：

[1] UNIV COLORADO,HLTH SCI CTR,SCH PHARM,DENVER,CO 80262

来源：

ADVANCED DRUG DELIVERY REVIEWS | 1993年 / 10卷 / 01期

关键词：

PROTEIN STABILIZATION; FREEZE-INDUCED DENATURATION; LYOPHILIZATION-INDUCED DENATURATION; PROTEIN DEGRADATION; CRYOPROTECTANT; CO-SOLUTE INDUCED STABILIZATION OF PROTEINS;

D O I：

10.1016/0169-409X(93)90003-M

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Proteins are marginally stable and hence readily denatured by various stresses encountered in solution, or in the frozen or dried states. Various additives are known to minimize the damage and to enhance the stability of proteins. This review discusses the current knowledge of the mechanisms by which these additives stabilize proteins against acute stresses, and also the various factors to be considered for long-term storage of proteins in solution.

引用

页码：1 / 28

页数：28

共 113 条

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[2]

AMBUDKAR SV, 1986, J BIOL CHEM, V261, P5596

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