Diagnosis of a cholecystocolonic fistula with liver abscess was made on a routine colescintigraphy in a patient with fever and hepatic space-occupying lesions of unknown cause. Unexpected scintigraphic findings were later confirmed by endoscopic retrograde cholangiopancreatography and at surgery. Hepatobiliary scintigraphy may serendipitously provide useful information about related organs in the dynamics of hepatic bile flow.