Long term safety and visibility of a novel liquid fiducial marker for use in image guided radiotherapy of non-small cell lung cancer

被引：15

作者：

de Blanck, Steen Riisgaard ^{[1
]}

Rydhog, Jonas Scherman ^{[1
,2
]}

Larsen, Klaus Richter ^{[3
]}

Clementsen, Paul Frost ^{[4
,5
]}

Josipovic, Mirjana ^{[1
,2
]}

Aznar, Marianne Camille ^{[1
,2
]}

af Rosenschold, Per Munck ^{[1
,2
]}

Jolck, Rasmus Irming ^{[6
,7
]}

Specht, Lena ^{[1
]}

Andresen, Thomas Lars ^{[6
]}

Persson, Gitte Fredberg ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Oncol, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen, Niels Bohr Inst, Blegdamsvej 17, DK-2100 Copenhagen, Denmark

[3] Bispebjerg Hosp, Dept Resp Med, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark

[4] Gentofte Univ Hosp, Dept Resp Med, Copenhagen, Denmark

[5] Rigshosp, CAMES, Copenhagen, Denmark

[6] Tech Univ Denmark, Ctr Nanomed & Theranost, Dept Micro & Nanotechnol, DTU Nanotech, Bldg 345E, DK-2800 Lyngby, Denmark

[7] Nanovi Radiotherapy AS, Diplomvej 373N, DK-2800 Lyngby, Denmark

来源：

CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY | 2018年 / 13卷

关键词：

Liquid fiducial marker; Image-guided radiotherapy; NSCLC; Endoscopic ultrasound; EBUS;

D O I：

10.1016/j.ctro.2018.07.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Safety and clinical feasibility of injecting a novel liquid fiducial marker for use in image guided radiotherapy in 15 patients with non-small cell lung cancer are reported. No major safety or toxicity issues were encountered. Markers present at start of radiotherapy remained visible in cone beam computed tomography and fluoroscopy images throughout the treatment course and on computed tomography images during follow-up (0-38 months). Marker volume reduction was seen until 9 months after treatment, after which no further marker breakdown was found. No post-treatment migration or marker related complications were found. (C) 2018 The Authors. Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology.

引用

页码：24 / 28

页数：5

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