KETO C-GLYCOSIDES - A NEW CLASS OF ANTITUMOR COMPOUNDS

被引:7
|
作者
HERSCOVICI, J [1 ]
BENNANIBAITI, MI [1 ]
FRAYSSINET, C [1 ]
ANTONAKIS, K [1 ]
机构
[1] CNRS,INST RECH SCI CANC,PATHOL CELLULAIRE LAB,F-94801 VILLEJUIF,FRANCE
关键词
D O I
10.1016/S0960-894X(00)80263-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of 4-keto unsaturated C-glycosides was synthesized from 0-acetyl C-glycosides. These compounds and some parent 2-keto unsaturated C-glycosides were tested for cytotoxic activity against LFCl2A cells (Rat hepatocarcinoma cells). C-Glycosides with an acyclic aglycone have not been found cyctotoxic, whereas 1-methyl cyclohexenyl and methylene cyclohexenyl C-glycosides possessed IC50 values of 9-0.03-mu-M with 11 being the most potent.
引用
收藏
页码:395 / 398
页数:4
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