1-PHENYLCYCLOALKYLAMINE DERIVATIVES .2. SYNTHESIS AND PHARMACOLOGICAL ACTIVITY

被引：141
作者：
KALIR, A
EDERY, H
PELAH, Z
BALDERMAN, D
PORATH, G
机构：
[1] Israel Institute, Biological Research, Ness-Ziona
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期
关键词：
D O I：
10.1021/jm00303a030
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of N,N-substituted 1-arylcyclohexylamines was prepared mainly by the reaction of an arylmagnesium bromide and 1-dialkylaminocyclohexanecarbonitrile. As the cyclopentyl analog could not be obtained by this way, condensation of 1-phenylcyclopentylamine with pentamethylene dibromide in DMF was tried with success. These compounds were tested for their psyehopharmacological properties. 1-[1-(2-Thienyl)cyclohexyl]piperidine (16) was found to be the most active. © 1969, American Chemical Society. All rights reserved.
引用
收藏
页码：473 / +
页数：1
相关论文
共 20 条
[1]  
BOVET D, 1961, SCI REP I SUPER SAN, V1, P127
[2]   EFFECTS OF PSYCHOTROPIC-DRUGS ON OPEN-FIELD BEHAVIOR IN RATS [J].
BRIMBLECOMBE, RW .
PSYCHOPHARMACOLOGIA, 1963, 4 (02) :139-147
[3]  
Bruylants P., 1924, B SOC CHIM BELG, V33, P467
[4]  
BUCHEL L, 1965, Therapie, V20, P467
[5]  
CATENACCI AJ, 1958, FED PROC, V17, P357
[6]  
CHAUVIERE G, 1963, B SOC CHIM FR, P1428
[7]   NEUROBIOLOGY OF PHENCYCLIDINE (SERNYL), A DRUG WITH AN UNUSUAL SPECTRUM OF PHARMACOLOGICAL ACTIVITY [J].
DOMINO, EF .
INTERNATIONAL REVIEW OF NEUROBIOLOGY, 1964, 6 :303-347
[8]   A NOTE ON A SIMPLE APPARATUS FOR DETECTING NEUROLOGICAL DEFICIT IN RATS AND MICE [J].
DUNHAM, NW ;
MIYA, TS .
JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION, 1957, 46 (03) :208-209
[9]  
GARATTINI S, 1957, PSYCHOTROPIC DRUG ED, P73
[10]   4-SUBSTITUTED PIPERIDINES .2. REACTION OF 1-BENZYL-4-CYANO-4-T-AMINOPIPERIDINES WITH ORGANOMETALLIC COMPOUNDS [J].
HERMANS, B ;
VANDAELE, P ;
VANDEWES.C ;
VANDEREY.C ;
BOEY, J ;
JANSSEN, PAJ .
JOURNAL OF MEDICINAL CHEMISTRY, 1965, 8 (06) :851-&
12