EXTENT OF FETAL OSSIFICATION AS AN INDEX OF DELAYED DEVELOPMENT IN TERATOGENIC STUDIES ON THE RAT

被引：201

作者：

ALIVERTI, V ^{[1
]}

BONANOMI, L ^{[1
]}

GIAVINI, E ^{[1
]}

LEONE, VG ^{[1
]}

MARIANI, L ^{[1
]}

机构：

[1] UNIV MILAN,INST PHARM,I-20133 MILAN,ITALY

来源：

TERATOLOGY | 1979年 / 20卷 / 02期

关键词：

D O I：

10.1002/tera.1420200208

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In teratogenic studies toxic effects may manifest themselves in retarded fetal development, such as a reduction in fetal weight. In searching for an additional index, the number of centers of ossification in seven skeletal districts (sternum, metacarpus, metatarsus, cervical and caudal vertebrae, anterior and posterior proximal phalanges) of rat fetuses delivered on days 19, 20 and 21 of gestation were counted and compared. Results showed uneven ossification in day‐19 and ‐20 fetuses, but sufficiently advanced, homogeneous an uniform ossification in day‐21 fetuses to provide a reliable quantitative index for evaluating retarded fetal development. It is therefore proposed that the stage of skeletal ossification in day‐21 fetuses be used in teratogenic studies in the rat to evaluate retarded fetal development. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：237 / 242

页数：6

共 11 条

[1] RELATION OF UTERINE VASCULATURE TO FETAL GROWTH AND INTRAUTERINE POSITION EFFECT IN RATS [J].