STUDIES ON KIDNEY-FUNCTION IN SUBJECTS EXPOSED TO ORGANIC-SOLVENTS .2. THE EFFECT OF DESMOPRESSIN IN A CONCENTRATION TEST AND THE EFFECT OF EXPOSURE TO ORGANIC-SOLVENTS ON RENAL CONCENTRATING ABILITY

The renal concentrating ability was studied in 11 [human] subjects by 14-16 h of fluid deprivation, alone and in combination with the vasopressin analog desmopressin. The effect of desmopressin without fluid deprivation on urinary osmolality was also studied. The combination of desmopressin and fluid deprivation was not superior to fluid deprivation alone for the production of concentrated urine. Desmopressin alone was inferior to the other 2 methods. No difference in renal concentrating ability could be demonstrated after 14 h of fluid deprivation, when comparing 118 subjects exposed [occupationally] to various organic solvents [styrene, xylene and toluene] with 48 controls.